The trouble with eating Italian food is that five or six days later, you're hungry again.

This is a one-liner built on comic exaggeration: Italian food is framed as so satisfying (or so abundant) that it keeps you full for nearly a week, with hunger returning only “five or six days later.” The humor depends on the mismatch between normal digestion and the absurdly long interval, a classic stand-up style of observational joke. It also plays on a familiar cultural association of Italian cuisine with hearty, filling meals. The line isn’t really a critique of Italian food; it’s a compliment delivered through hyperbole, using mock “trouble with…” phrasing to set up a positive punchline.