Be able to be alone. Lose not the advantage of solitude.

The line commends solitude not as isolation or misanthropy, but as a practiced capacity: the ability to be alone without restlessness, fear, or dependence on company for meaning. “Lose not the advantage of solitude” frames aloneness as a resource—time in which one can examine conscience, order thoughts, pray or meditate, and recover independence of judgment. Browne implies that those who cannot bear their own company are vulnerable to conformity and to the moral noise of society. The quote thus elevates solitude as a discipline that strengthens interior life and makes social engagement more deliberate rather than compulsive.