Cynics always say no. Saying yes leads to knowledge. So for as long as you have the strength to, say yes.

The line contrasts cynicism—defined here as reflexive negation—with an ethic of openness. Colbert frames “yes” not as naïve agreement but as a posture of engagement: consenting to experience, conversation, risk, and uncertainty is what produces learning. The final clause (“for as long as you have the strength to”) acknowledges that affirmation can be demanding; it requires emotional and moral stamina, especially when life is painful or complicated. In that sense, the quote functions as both advice and a credo: knowledge and growth come from participation rather than withdrawal, and the courageous response to the world is often to remain receptive.