I think Mr. Wilson will have to be the rest of the way alone.

On its face, the line reads as a dry, self-referential joke: the speaker (Flip Wilson) treats “Mr. Wilson” as a separate person who must proceed “alone,” as if the comedian is stepping away from his own identity. The humor depends on a mock-formal third-person framing that creates distance between the performer and the name, suggesting a comic split between public persona and private self. It can also be heard as a wry comment on celebrity—“Mr. Wilson” as the brand that continues on, even when the individual is tired of carrying it. Without a verified source, however, any deeper situational meaning remains speculative.