God has a most wicked sense of humor.

Taken at face value, the line expresses a wry, even bitter, theistic irony: life’s reversals can feel so pointedly ill-timed or disproportionate that they resemble a dark joke authored by a higher power. In O’Hara’s mouth (as the attribution suggests), it would fit her public persona of blunt candor and hard-earned resilience—an acknowledgment that fate can undercut human plans with comic cruelty. The phrasing also works as a secular idiom: “God” functions less as doctrine than as shorthand for chance, destiny, or the universe’s indifference, with “wicked” signaling both moral protest and gallows humor.