I know how to do anything, I’m a mom.

The line is a comic boast that frames motherhood as a crash course in practical competence. It implies that parenting forces a person to become a generalist—problem-solver, organizer, negotiator, nurse, mechanic, and emotional anchor—often without formal training or recognition. The humor comes from the exaggerated certainty (“anything”), but the underlying point is serious: mothers routinely acquire skills through necessity, improvisation, and persistence. In the context of Roseanne Barr’s public persona and working-class comedy, the sentiment also reads as a defense of domestic labor as real expertise, challenging the tendency to undervalue it.