You know that look that women get when they want to have sex? Me neither.

The humor hinges on a quick reversal: it begins as if the speaker is about to describe a familiar, shared experience, then undercuts that expectation with “Me neither,” revealing the speaker’s lack of sexual success. The line uses self-mockery to expose insecurity and loneliness while also parodying the way men sometimes talk about women’s desire as something legible or “obvious.” Its bluntness and brevity make it a classic stand-up construction—setup, misdirection, punchline—where the laugh comes from the speaker’s sudden admission of cluelessness and exclusion.