When life gives you lemons, squirt someone in the eye.

The joke works by subverting the motivational proverb "When life gives you lemons, make lemonade." Instead of converting adversity into something productive, the speaker opts for petty, impulsive retaliation—an absurdly literal use of lemons as a weapon. Read as satire, it captures the feeling that upbeat advice can be inadequate or even insulting when someone is overwhelmed. The humor lies in the gap between what one is supposed to do (be resilient, be constructive) and what one sometimes wants to do (lash out). In Guisewite’s comedic world, the line becomes a shorthand for venting frustration and acknowledging imperfect coping mechanisms.