I prefer an accommodating vice to an obstinate virtue.

The line sets social ease and flexibility against moral rigidity. “Accommodating vice” suggests a person who may be flawed but is pleasant, adaptable, and willing to meet others halfway; “obstinate virtue” suggests someone technically righteous yet inflexible, censorious, or impossible to live with. The paradox is comic and satirical: it punctures self-satisfied moralism by implying that virtue without charity, tact, or humanity can become a kind of vice in practice. Read this way, the remark is less a defense of wrongdoing than a critique of sanctimony and an argument for sociability—one of Molière’s recurring targets in his comedies, where hypocrisy and hard-edged “principle” often mask pride.