Sex is God's joke on human beings.

The line frames sexuality as a cosmic practical joke: an overwhelming, often irrational drive that can upend dignity, judgment, and carefully constructed social roles. By invoking “God,” the quip suggests that the tension between bodily appetite and human ideals (romance, morality, self-control) is built into the human condition rather than merely a personal failing. Read as Bette Davis–style barbed wit, it also carries a note of disillusionment about how sex complicates love and power—how it can make people behave against their own interests, and how society simultaneously obsesses over it and polices it. The humor works by compressing that contradiction into a single, cynical epigram.