Never does nature say one thing and wisdom another.

The line asserts a harmony between what is “natural” and what is truly “wise”: sound judgment does not contradict the basic facts of human nature or the order of the world. Read this way, it is a rebuke to sophistry and self-deception—arguments that try to make vice, excess, or cruelty seem reasonable by dressing them up as cleverness. It also implies that moral insight is not an artificial overlay on life but something that, at its best, reads nature correctly. In later reception, the sentiment is often taken in a broadly Stoic or natural-law direction: genuine wisdom aligns with nature rather than opposing it.